LINE予約・相談
Medically reviewed by
Dr. Pim Thaweewitayarut — Board-certified Dermatologist
MSc Dermatology, King’s College London · Best thesis award in acne treatment
Sylfirm X is a microneedle RF device, while Rejuran is a salmon-PN skin booster — different tools for firmer, clearer skin. This guide compares how they work, which may suit your concern, whether to combine them, and what each costs in Bangkok.
What You’ll Learn in This Article
- How Sylfirm X and Rejuran differ in mechanism
- Which may suit your main concern, and who each suits
- Whether the two can be combined, and possible side effects
- What each costs at Bibi Clinic in Bangkok
Table of Contents
Curious whether Sylfirm X or Rejuran is right for you?
The Short Answer
Sylfirm X and Rejuran address overlapping problems in different ways. Sylfirm X is an energy-based microneedle radiofrequency (RF) treatment that heats the deeper skin to firm and tighten, and is often chosen for melasma, redness and pores.
Rejuran is an injectable skin booster made from salmon polynucleotides (PN) that supports the skin’s own repair, and is generally chosen for firmness, glow, fine lines and acne marks.
Neither is simply better; the right choice depends on your main concern, and many people use them together. At Bibi Clinic both are physician-led, and your plan is confirmed at consultation. Individual results vary.
What Each Treatment Is and How It Works
Before comparing them, it helps to know what category each falls into. That one fact explains most of the differences below.
Sylfirm X combines microneedling with radiofrequency. Ultra-fine needles deliver controlled heat into the dermis across eight modes, which may prompt the skin to rebuild collagen while the surface stays largely undisturbed. It is generally used for melasma, redness, pores, texture and early laxity. [1][2]
Rejuran is a skin booster injected into the skin. Its salmon-derived polynucleotides support the skin’s own repair processes, and published reviews of polynucleotides in aesthetic medicine report improvements in skin texture and elasticity, with generally mild and transient side effects. [3] It works from within rather than by heating tissue, which is why it is usually described as a skin-quality treatment rather than a tightening device.
The treatment process
- Consultation. A physician assesses your skin and medical history and recommends one treatment, the other, or a sequence of both.
- Numbing. Both are performed after a topical anaesthetic is applied for comfort.
- Treatment. Sylfirm X passes a handpiece over the mapped areas; Rejuran is injected into the skin in small amounts across the treatment area.
- Aftercare. The skin is soothed and aftercare advice is given, including sun protection and moisturising.
Sylfirm X vs. Rejuran: Side by Side
They are not really rivals — they are different tools for different jobs, and once that is clear, choosing gets much simpler. One reworks skin quality with heat and needling; the other supplies the skin with a repair-supporting material. Here is how the two line up on what actually affects your decision.
| Feature | Sylfirm X | Rejuran |
|---|---|---|
| How it works | Microneedle RF energy | Salmon-PN injections |
| Often chosen for | Melasma, redness, pores, firmness | Firmness, glow, fine lines, acne marks |
| Typical course | 3–6, monthly | 3, about a month apart |
| Downtime | Redness 1–2 days | Small bumps settle fast |
| From | 12,600 THB / session | 12,900 THB / 2cc |
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Which Is Right for Your Concern?
Neither one wins outright — it comes down to which suits the concern you most want to address. Start with whatever bothers you most, remembering that results differ from person to person.
- Melasma, redness or a flushed look — Sylfirm X, thanks to its pigment-and-vascular mode
- Dryness, dullness or fine lines — Rejuran, which supports hydration and glow from within
- Enlarged pores or uneven texture — either may help; Sylfirm X often leads
- Acne marks — both may help, and a combined plan is common
Because skin is individual, the clearest way to decide is a consultation. You can read more on the Sylfirm X treatment page and the Rejuran skin booster page.
Neither treatment suits everyone. Both are generally avoided in pregnancy and breastfeeding, over active skin infection or inflammation, and in certain medical conditions; Sylfirm X is also generally avoided with pacemakers, other implanted electronic devices or a keloid tendency, and Rejuran is not appropriate for anyone with a relevant allergy, including to fish-derived material. A qualified physician makes the final judgement.
Can You Combine Them?
Often yes, and they are frequently paired. The clinic may recommend combining an energy treatment with a booster for a complementary result: Sylfirm X works from deeper down, while a booster like Rejuran supports hydration and firmness nearer the surface.
Typically they are sequenced under medical guidance rather than done on the same day, with the timing tailored to how your skin responds along the way. Your physician plans the order and spacing so the two support rather than crowd each other. For many people that means a short Sylfirm X course for tone and firmness, with a booster added along the way.
Possible side effects
- Redness and warmth, usually peaking within one to two days
- Mild swelling, and tiny microneedle points that typically close within about four hours
- Pain or a pricking sensation during and shortly after the session
- Bruising in the treated area
- Temporary dryness or flaking as the surface settles
- Post-inflammatory hyperpigmentation, or a temporary worsening of melasma
These vary from person to person. Careful sun protection supports pigment outcomes, and anything unexpected or persistent should be reviewed by a physician.
With Rejuran, small bumps, swelling, redness, bruising or tenderness at the injection points are also possible and usually settle quickly. Allergic reactions are uncommon but possible.
Pricing at Bibi Clinic in Bangkok
Both treatments are priced by the number of sessions or the volume used, which depends on your individual goals. The menu below is listed openly; your exact plan is confirmed at consultation, never estimated in advance.
| Menu | Session or Area | Price (THB) |
|---|---|---|
| Sylfirm X | 1 session, face | 12,600 THB |
| Sylfirm X | 3 sessions, face | 31,800 THB |
| Sylfirm X | 6 sessions, face | 58,600 THB |
| Sylfirm X – add neck | Optional add-on, per session | 3,000 THB |
| Rejuran | 2cc | 12,900 THB |
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Prices are as of August 2026 and are subject to change. Please see our price list page or ask at your consultation for the latest fees.
At Bibi Clinic, treatment is physician-led, with a whole-face assessment and a personalised plan, and support in English, Japanese and Thai. For the full, current menu, see our price list or the Sylfirm X treatment page.
Considering Sylfirm X or Rejuran in Bangkok?
If you are considering Sylfirm X or Rejuran in Bangkok, Bibi Clinic offers a personalised consultation with an experienced aesthetic physician — in English, Japanese or Thai.
Frequently Asked Questions
Q. Is Sylfirm X or Rejuran better for melasma?
A. Sylfirm X is more often chosen for melasma, since its pulsed-wave mode targets pigment and redness. Rejuran focuses more on hydration and firmness.
Q. Which has less downtime?
A. Both are generally low. Sylfirm X may bring redness for one to two days, while Rejuran may leave small bumps that usually settle quickly.
Q. Can I have both treatments?
A. Often yes. They are frequently combined for a complementary result, and your physician sets the order and timing at consultation.
Q. Which is cheaper?
A. They differ by plan. Sylfirm X starts at 12,600 THB per session and Rejuran is 12,900 THB for 2cc, as of August 2026. Please confirm at consultation.
Q. Which lasts longer?
A. Both build gradually and are maintained over time. Longevity varies with skin and plan, so results differ between people.
References
- [1] Radiofrequency Microneedling for Facial Rejuvenation: A Systematic Review. Journal of Cosmetic Dermatology / PubMed, 2026.
- [2] A Scoping Review of Radiofrequency Microneedling: Clinical Application and Outcome Assessment. Aesthetic Plastic Surgery / PubMed, 2025.
- [3] The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review. Journal of Cosmetic Dermatology / PubMed, 2025.
- [4] Sylfirm X — treatment details and pricing. Bibi Clinic.
- [5] Rejuran — treatment details and pricing. Bibi Clinic.
Ready to Take the First Step at Bibi Clinic?
The first step is always a free, no-obligation physician consultation.
Location: 3rd Floor, Room 306, Hotel Nikko Bangkok, 27 Sukhumvit Soi 55 (Thonglor), Khlong Tan Nuea, Wattana, Bangkok 10110
BTS: Thonglor Station — 3-minute walk
Hours: Monday – Sunday, 9:00 – 19:00
Language: English, Japanese, and Thai
WhatsApp: +66 62 516 6622 | Tel: 062-516-6622 | Instagram: @bibi_clinic_en
Links: https://bibi-beauty.com/en/
Disclaimer: This article is for informational purposes only and does not constitute medical advice. Individual results vary. Please consult a qualified medical professional before undergoing any aesthetic treatment. Bibi Clinic’s physicians will assess your personal suitability during a consultation.
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