Medically reviewed by

Dr. Pim Thaweewitayarut — Board-Certified Dermatologist

MSc in Dermatology, King’s College London · Best Thesis Award in Acne Treatment

Rejuran is a salmon-derived polynucleotide (PN) skin booster that supports skin repair and can help reduce the appearance of acne scars. In Bangkok, it is often chosen to address uneven skin texture, enlarged-looking pores, and shallow scarring.

This guide explains how it works, who it's for, and what to expect.

Table of Contents

The Short Answer

Rejuran is a polynucleotide (PN) skin booster made from salmon DNA that helps support the skin’s natural repair and renewal processes. For acne scars, it tends to be most effective at texture, shallow marks, and enlarged-looking pores — rather than deep, crater-like scars, which usually require a combination of treatments. A typical treatment plan consists of three sessions spaced about a month apart, followed by a maintenance session roughly every six months. Improvements build up gradually over several weeks and vary from person to person. Rejuran isn’t suitable for everyone—such as those with a fish allergy—so treatment begins with a doctor’s evaluation.

How Rejuran Addresses Acne Scars and Pores

Acne can leave behind several different types of marks: flat discoloration, rough texture, enlarged-looking pores, and indented scars. Rejuran does not fill these in the way a contouring filler would. Instead, it supports the skin’s natural healing process and may help reduce inflammation,^[1] As a result, the skin gradually becomes smoother and more even over the course of several sessions.

It tends to be most effective for improving skin texture, shallow scarring, and the appearance of those marks, as well as enlarged-looking pores and general dullness. Deep “crater” or ice-pick scars usually require a combination of treatments, such as resurfacing or subcision, and your doctor may suggest pairing Rejuran with another treatment.

The Treatment Process

1. Consultation and skin assessment. The doctor examines your skin and discusses the injection sites and dosage with you.
2. Topical anesthetic applied before treatment begins.
3. Injection (about 15–30 minutes), Applied by hand for careful, section-by-section placement around scars and pores.
4. Aftercare instructions, with additional sessions and maintenance scheduled based on your scar type.

Who Is It Suitable For?

Rejuran is generally suitable for people concerned about skin texture, shallow acne scars, and enlarged-looking pores who are looking for gradual improvement rather than an instant fix. Rejuran is not suitable for everyone; a doctor will review your medical history, but treatment is generally not offered for:

• Women who are pregnant, breastfeeding, or who may be pregnant.
• People taking NSAIDs, immunosuppressants, or antiplatelet or anticoagulant medications.
• People with autoimmune conditions, such as sarcoidosis.
• Anyone with an allergy to fish or fish roe, or hypersensitivity to sodium polynucleotide.
• Those who have recently had, or plan to have, non-absorbable fillers, or who have active inflammation or infection.

Always tell your doctor about any allergies or medications you are taking, and ask any questions before proceeding. The medication used at Bibi Clinic is approved by the Thai FDA.

Sessions, Downtime, and What to Expect

For acne scars and skin texture, three sessions about a month apart is a common starting point. Even a single session can make a difference, though concerns related to scars often seem to respond better once all three sessions are complete. After the first session, many people notice that their skin feels more hydrated and looks a little calmer; changes in texture and the appearance of pores tend to become more noticeable over the course of the second and third sessions, developing gradually over several weeks rather than overnight.

Downtime is usually minimal. Small bumps may appear immediately after treatment and typically subside within a few hours; any bruising or swelling generally resolves within 1–2 weeks. You can usually wear makeup starting the next day.

Possible side effects

• Small bumps appear immediately after treatment but subside within hours.
• Bruising or swelling, which generally resolves within 1–2 weeks.
• It’s best to avoid long baths, saunas, alcohol, and intense exercise for about a week, and to limit exposure to strong sunlight for 1–2 weeks—something worth keeping in mind if you’re visiting Bangkok.

Once you’ve completed the first three sessions, a maintenance session about every six months can help you maintain the results.

Rejuran vs. Rejuran i: What You Need to Know

Two versions are used depending on the area and the sensitivity of the skin—choosing the right one is important for under-eye and peri-oral concerns that often occur alongside acne scars.

Scroll sideways to see more →

As part of a treatment plan, the two types can also be combined—standard Rejuran for the cheeks and overall skin texture, and Rejuran i for areas where the skin is thinner. Your doctor will determine the appropriate combination based on your specific concerns.

Pricing at Bibi Clinic in Bangkok

Pricing is based on the volume per session; the exact volume required depends on your scarring and the areas being treated, as confirmed during the consultation.

Scroll sideways to see more →

At Bibi Clinic, injections are performed manually by doctors, allowing for careful, area-by-area application around scars and pores. If pores are a particular concern, the clinic’s Rejuran Skin Booster Page has more details.

Frequently Asked Questions

Rejuran or Rejuran i for under-eye scarring?

Rejuran i is lighter and is better suited for the delicate skin under the eyes; standard Rejuran is used for the cheeks and overall skin texture.

How much downtime is there?

Minimal. Minor bumps subside within hours; any bruising or swelling usually clears up within 1–2 weeks.

Can I receive Rejuran treatment if I have a fish allergy?

No—an allergy to fish or fish roe is a contraindication. Be sure to tell your doctor your full medical history during your consultation.

Can Rejuran treat deep, crater-like acne scars?

It tends to be most effective for improving skin texture, shallow marks, and pores, rather than deep, crater-like scars. For deeper scarring, your doctor may recommend combining Rejuran with another treatment, such as skin resurfacing or subcision.

How many sessions will I need?

A common starting point is three sessions spaced about a month apart, followed by a maintenance session roughly every six months. Your doctor will determine the appropriate plan during your consultation.

References

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Individual results may vary. Please consult a qualified medical professional before undergoing any aesthetic treatment. Bibi Clinic’s physicians will assess your personal suitability during a consultation.