Medically reviewed by

Dr. Pim Thaweewitayarut — Board-Certified Dermatologist

MSc in Dermatology, King’s College London · Best Thesis Award in Acne Treatment

Rejuran is an injectable polynucleotide (PN) skin booster derived from salmon DNA that supports skin regeneration. In Bangkok, it is a popular non-surgical treatment for improving skin firmness, texture, and radiance.

This guide explains how it works, the sessions, downtime, and cost.

Table of Contents

The Short Answer

Rejuran is a skin booster made from polynucleotides (PN) extracted from salmon DNA, which is why it’s nicknamed the “salmon injection.” Rather than adding volume like a filler, it works from within to support the skin’s own repair process, helping to thicken the epidermis and dermis and improving firmness, hydration, and texture. A typical treatment plan consists of three sessions spaced about a month apart, followed by maintenance every six months. Results usually last somewhere between 6 and 12 months, although it depends on the person, and downtime tends to be minimal.

What Is Rejuran?

Rejuran is a skin booster containing polynucleotides (PN), long-chain fragments that support repair, regeneration, and renewal in the skin. Unlike a hyaluronic acid filler, which physically plumps a line, Rejuran addresses a broader issue: the overall quality of your skin. Published reviews note that PN compounds may help support tissue repair and reduce inflammation.^[1] Day to day, this can result in a smoother texture, skin that retains moisture better, and a more even, refreshed-looking complexion. It can be used all over the face, as well as on the forehead, neck, and décolletage.

It’s also different from collagen-stimulating injectables: a filler is about shape, a stimulator gradually encourages the skin to produce new collagen for structure, while Rejuran focuses on the condition of the skin itself. The product used in the treatment is approved by the Thai FDA.

The Treatment Process

1. Cleansing and skin assessment. The doctor examines your skin and discusses the injection sites and dosage with you.
2. Topical anesthetic applied before treatment begins.
3. Injection (about 15–30 minutes) performed manually by the doctor.
4. Aftercare instructions, with a follow-up plan that includes additional sessions and maintenance.

Who Is It Suitable For?

Because it addresses skin quality rather than shape, Rejuran is suitable for a range of everyday concerns, including loss of firmness and radiance, rough or uneven texture and enlarged-looking pores, fine lines caused by dryness and aging, the appearance of acne marks and shallow scarring, and under-eye dark circles caused by poor circulation. Rejuran is not a lifting procedure; for pronounced sagging, a doctor may suggest combining it with other treatments.

This treatment is generally not suitable for women who are pregnant, breastfeeding, or who may be pregnant; people taking NSAIDs, immunosuppressants, or antiplatelet or anticoagulant medications; those with autoimmune conditions such as sarcoidosis; anyone with an allergy to fish or fish roe, or hypersensitivity to sodium polynucleotide; and those with active inflammation or infection. Always inform your doctor of any allergies or medications you are taking during your consultation.

Sessions, Results, and How Long They Last

Many people notice early improvements—such as firmer skin, a healthy glow, and brighter under-eye areas—after just one session. For skin texture, fine lines, and acne scars, the recommended plan is three sessions spaced about one month apart, followed by maintenance every six months. Changes in texture and elasticity tend to become more noticeable over several weeks, and results generally last 6 to 12 months, depending on the formula used and your initial skin condition.

The visit is brief: your skin is cleansed, a doctor examines your skin and determines the injection sites and dosage, a topical anesthetic is applied, and the injection itself usually takes about 15 to 30 minutes.

Possible side effects

• Small bumps may appear immediately after treatment, but they usually subside within a few hours.
• Bruising or swelling may occur, but these symptoms generally resolve within 1–2 weeks.
• It’s a good idea to avoid long baths, saunas, alcohol, and intense exercise for about a week, and prolonged sun exposure for 1–2 weeks.

Injections at Bibi Clinic are performed manually by doctors, not by an automated device, so placement is tailored to each area. For comfort, the clinic also offers a Pain-Free Rejuran This formulation is used in conjunction with topical anesthesia. Most people resume their normal activities the same day.

Rejuran vs. Rejuran i

Rejuran is not a one-size-fits-all product—there is a milder version available for more delicate areas.

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Pricing at Bibi Clinic in Bangkok

Pricing at Bibi Clinic is straightforward and based on the volume used per session; your exact volume is confirmed during the consultation and is never estimated in advance.

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When comparing clinics, it’s worth looking beyond the headline figure—manual, doctor-led placement allows the dose to be adjusted on a region-by-region basis. For the complete, up-to-date menu, see the Rejuran Skin Booster Page.

Frequently Asked Questions

How long does Rejuran last?

Results generally last 6 to 12 months, depending on the formula and your skin. A touch-up every six months helps maintain them.

Can I see results after just one session?

Many patients notice improved firmness and a more radiant complexion after just one session. For skin texture, fine lines, and acne scars, three sessions are generally recommended.

How much downtime does Rejuran require?

Usually minimal. Minor bumps subside within hours; any bruising or swelling typically clears up within 1–2 weeks.

Is Rejuran painful?

You may experience some discomfort. The clinic uses topical anesthesia and a pain-reducing formula to ensure your treatment is comfortable.

What’s the difference between Rejuran and Rejuran i?

Rejuran is designed for overall skin rejuvenation across the entire face, while Rejuran i has a lighter formulation specifically developed for delicate areas such as around the eyes.

References

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Individual results may vary. Please consult a qualified medical professional before undergoing any aesthetic treatment. Bibi Clinic’s physicians will assess your personal suitability during a consultation.