Neauvia NEAUVIA®
Next-generation hyaluronic acid formulation of PEG cross-linked with excellent elasticity and viscosity
- PEG cross-linking prevents delayed allergic reaction
- Long-term volumizing effects can be expected.
- High heat resistance and synergistic effect with heat treatment on the same day
- Skin has lost its elasticity.
- Looking for hyaluronic acid with a natural finish.
- I want my skin to glow.
- Sagging and pores are a concern.
- I want to achieve skin growth and volume enhancement at the same time.
- Worried about allergy from hyaluronic acid injections
For Concerns Like These
Neauvia
is a Great Option
It has a highly elastic texture
Hyaluronic acid formulation using PEG cross-linking
Neauvia® is a hyaluronic acid formulation launched in 2014. It uses PEG (polyethylene glycol) as the cross-linking agent (additive) instead of the conventional BDDE (1,4-butanediol diglycidyl ether). the use of PEG cross-linking provides a highly elastic texture, allowing for a more natural-looking result. It also contains two amino acids, glycine and L-proline, which make it easier to maintain the shape, skin firmness, and elasticity after injection. Nuvia was the first hyaluronic acid product to receive MDR (European Medical Device Regulation) approval, and is currently sold in more than 80 countries worldwide. Nuvia is available in several formulations that differ in terms of the areas in which it can be injected and the ingredients used, and Bibi Clinic uses two formulations, "INTENSE" and "STIMULATE.
INTENSE
Hyaluronic acid concentration 28mg/ml
Intended use: Volumizing
Main injection sites: nose, base of nasal wings, chin, facial lines, etc.
STIMULATE
Hyaluronic acid concentration 26mg/ml, CaHA (calcium hydroxyapatite) 1%.
Intended use: Volume enhancement + collagen activation
Main injection sites: forehead, temples, mid-face, chin, etc.
Before & After
| Treatment Details | Neauvia Intense Nose 1cc, Restylane Lyft Lines 0.5cc each |
|---|---|
| Treatment Frequency |
1 time |
| Side Effects Risks |
Mild redness and swelling (several days to a week), internal bleeding, unevenness, etc. |
| Costs | 41,600B |
| Treatment Details | Neauvia Intense nasal 1cc, Restylane Lyft cheek 1cc |
|---|---|
| Treatment Frequency |
1 time |
| Side Effects Risks |
Swelling, internal bleeding (varies by individual/about several days), unevenness, etc. |
| Costs | Neauvia Intense: 20,800B, Restylane Lyft: 14,800B |
BIBI CLINIC
Neauvia Features
-
It is suitable for PEG cross-linking and is relatively unlikely to cause allergic reactions.
Relatively unlikely to cause allergiesHyaluronic acid preparations contain additives called "cross-linkers" to slow the breakdown and absorption of hyaluronic acid in the body. BDDE is generally added to conventional hyaluronic acid preparations, but it has been pointed out that BDDE may contribute to allergic reactions after hyaluronic acid injections. However, it has been pointed out that BDDE may contribute to allergic reactions after hyaluronic acid injections. No delayed allergic reactions have been reported with the use of Nuvia since the start of clinical trials in 2012. *
*As of July 2025
-
It offers high heat resistance and same-day heat treatment, allowing synergistic effects to be expected.
Synergistic effects can be expectedPEG is also characterized by high thermostability: a study comparing the thermostability of BDDE- and PEG-crosslinked hyaluronic acid formulations showed that BDDE-crosslinked hyaluronic acid decreased by more than 30% after heating, while PEG-crosslinked hyaluronic acid formulation showed no change even at temperature changes from -20 to 75°C. The PEG-crosslinked hyaluronic acid formulation showed no change, even at temperatures ranging from -20 to 75°C. *This means that Nuvia can be combined with cosmetic medical devices such as infrared, RF radiofrequency, and Hyf on the same day of the Nuvia treatment. The high heat resistance of Nuvia also makes it less susceptible to temperature changes during transportation and storage, which has the added benefit of making it easier to maintain the quality of the hyaluronic acid formulation.
Bibi Clinic offers treatments with cosmetic medical devices such as Volnuma and Silpharm X. If you are interested in a combined approach in conjunction with Nuvia, please feel free to contact us.*Heat Influence on Different Hyaluronic Acid Fillers
Effects of Heat on Various Hyaluronic Acid Injectables
Author:P.Kubik1,W.Gruszczyński1
Publication:Journal of Applied Cosmetology,Vol 41 iss. 2 Jul-Dec,2023:.
Price List
Neauvia
| INTENSE | 20,800B |
| STIMULATE | 20,800B |
BIBI CLINIC
Why choose Neauvia?
-
POINT
Skin diagnosis to determine the most effective injection site and amount of injection.
In hyaluronic acid injection procedures, not limited to Nuvia, it is important to determine where and how much hyaluronic acid product to inject. We use a "high-performance skin diagnostic machine: VISIA®" to diagnose the patient's skin.
What is VISIA®, a high-performance skin diagnostic machine?
Skin image diagnostic equipment that analyzes photos taken with a high-performance camera to quantify and visualize internal skin blemishes and blemish reserves, wrinkles, pores, acne, and skin age that are invisible to the naked eye.
Patients who undergo Nuvia injections at Bibi Clinic receive a complimentary set of VISIA® (also available as a stand-alone product for a fee), and our approach is to bring patients closer to their ideals through the synergy of accurate skin diagnosis with VISIA® and Nuvia's pursuit of natural-looking results.
-
POINT
Offering Japanese Aesthetics and Quality in Bangkok, Thailand
Bibi Clinic is a clinic offering Japanese-style cosmetic medicine in Bangkok, Thailand. Thai doctors under the guidance of Dr. Hotta, the president of BIANCA CLINIC, which boasts a large number of cases in Japan, carefully attend to patients' requests. For hyaluronic acid injections such as Nuvia, Dr. Hotta has introduced the "BIANCA-style hyaluronic acid METHOD," which he has developed over more than 10 years. We are pursuing the "natural beauty without overdoing it" that Japanese people prefer, in which the amount of injections is kept to a minimum while still providing a firm change in appearance. We provide Japanese quality cosmetic treatment for those who live in Thailand and those who visit Bangkok on vacation.
Treatment process
01
counseling
A skin diagnosis is performed using VISIA® to determine the injection site, the amount to be injected, and which of Nuvia's drugs to use.
02
make-off
If you are coming to the hospital with makeup on, we will ask you to remove it before injecting it into your face.
03
Treatment
Comfort Measures
Comfort Measures
Nuvia is injected into the face. The procedure takes about 30-60 minutes.
| Treatment Duration | Approximately 30–60 minutes per session |
|---|---|
| Recommended Frequency | About 1 to 2 times *There are individual differences. |
| Bath & Face Washing | It is allowed on the same day, but prolonged heat exposure should be avoided. |
| Makeup | It can be done from the day of the procedure, but please avoid applying pressure, massaging, or rubbing the injection site. |
| Contraindications | Treatment is not available for: - Have allergic reactions to hyaluronic acid products, local anesthetics, or gram-positive bacterial proteins - Are currently pregnant *Please ask your doctor for details. |
| Possible Side Effects and Risks | Pain, swelling, bruising, allergic reactions, asymmetry, infection, and rare nerve injury. |
| About the Device | Except for products that have received regulatory approval, there are no other domestically approved drugs or medical devices with the same ingredients or performance. CE Mark obtained under MDR (European Medical Device Regulations). |
FREQUENTLY ASKED QUESTIONS
Q What is the difference between Nuvia and other common hyaluronic acid products?
A
It can be performed from the day of the procedure, but pressure, massage, and friction on the injection site should be avoided, and because the formulation does not use BDDE cross-linking found in conventional hyaluronic acid products, the risk of delayed allergic reactions is reduced; furthermore, PEG cross-linking provides a highly elastic texture and superior heat resistance, allowing same-day combination with cosmetic medical device treatments, while the addition of glycine and L-proline is expected to further enhance the elasticity and stability of the hyaluronic acid.
Q How do I choose the type of Nuvia?
A Bibi Clinic uses two types of Nuvia formulations: INTENSE is PEG cross-linked hyaluronic acid and STIMULATE is PEG cross-linked hyaluronic acid plus calcium hydroxyapatite. Which formulation is more suitable for you can be discussed during your consultation.
Q How long do the effects of Nuvia last?
A In the case of INTENSE, the effect can be expected to last for about 12 months, depending on the individual. The peak effect is said to be around one month after the treatment.
Q Is the Nuvia procedure painful?
A During the Nuvia procedure, there will be pain similar to that of an injection, but local anesthesia will be used to minimize pain. If you are concerned about pain, please consult us at the time of consultation.
Q Is there any downtime?
A The Nuvia procedure is characterized by very little downtime. Swelling, redness, internal bleeding, and swelling may appear after the procedure, although the course of the procedure varies from person to person. A dull ache may be felt at the site of injection, but in most cases this will diminish within a few days.
Q Can I consult with you in Japanese about the Nuvia treatment?
A Bibi Clinic in Bangkok, Thailand, is available in Thai, Japanese, and English, so Japanese patients can consult with us with confidence. Explanations about Nuvia and pre-treatment counseling are also available in Japanese. We also offer free counseling, so please feel free to contact us.
If you would like to do Neauvia
BIBI CLINIC
Address
27 3rd Floor, Room 306, Sukhumvit 55 (Thonglor), Khlong Tan Nuea, Wattana, Bangkok, 10110
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