Medically reviewed by

Dr. Pim Thaweewitayarut — Board-certified Dermatologist

MSc Dermatology, King’s College London · Best thesis award in acne treatment

Rejuran is a salmon-derived polynucleotide (PN) skin booster that supports repair and can soften the look of acne marks. In Bangkok it is often chosen for uneven texture, enlarged-looking pores and shallow scarring.

This guide explains how it works, who it suits and what to expect.

Table of Contents

The Short Answer

Rejuran is a polynucleotide (PN) skin booster made from salmon DNA, which helps support the skin’s own repair and renewal. For acne scarring, it tends to do most for texture, shallow marks and enlarged-looking pores — rather than deep, crater-like scars, which usually need a combination of treatments. A common plan is three sessions about a month apart, followed by a maintenance session roughly every six months. Improvements build up gradually over several weeks and vary from person to person. Rejuran isn’t right for everyone, such as those with a fish allergy, so it starts with a doctor’s assessment.

How Rejuran Approaches Acne Scars and Pores

Acne can leave a few different marks behind: flat discolouration, rough texture, pores that look enlarged, and indented scarring. Rejuran doesn’t fill these in the way a shaping filler would. Instead, it supports the skin’s repair process and may help ease inflammation,^[1] so the skin gradually looks smoother and more even over a course of sessions.

Where it tends to help most is texture, shallow scarring and the look of those marks, along with enlarged-looking pores and general dullness. Deep “crater” or ice-pick scars usually call for a combination approach, such as resurfacing or subcision, and your doctor may suggest pairing Rejuran with another treatment.

The treatment process

1. Consultation and skin assessment. The doctor checks your skin and agrees the sites and amount with you.
2. Topical anaesthetic applied before treatment begins.
3. Injection (about 15–30 minutes), done by hand for careful, area-by-area placement around scars and pores.
4. Aftercare guidance, with further sessions and maintenance planned around your scar type.

Who Is It Suitable For?

Rejuran generally suits those with texture concerns, shallow acne marks, and enlarged-looking pores who want gradual improvement rather than an instant fix. Rejuran is not suitable for everyone; a doctor will check your history, but treatment is generally not offered for:

• Those who are pregnant, breastfeeding, or may be pregnant.
• People taking NSAIDs, immunosuppressants, or antiplatelet or anticoagulant medicines.
• Those with autoimmune conditions, such as sarcoidosis.
• Anyone with an allergy to fish or fish roe, or hypersensitivity to polynucleotide sodium.
• Those who have recently had, or plan to have, non-absorbable fillers, or who have active inflammation or infection.

Always tell your doctor about allergies and medications, and ask any questions before you proceed. The medication used at Bibi Clinic is approved by the Thai FDA.

Sessions, Downtime and What to Expect

For acne marks and texture, three sessions about a month apart is a common starting point. Even one session can make a difference, though scar-related concerns often seem to respond better once all three are complete. After the first session, many people notice their skin feels better hydrated and looks a little calmer; changes to texture and the look of pores tend to become clearer across the second and third sessions, over several weeks rather than overnight.

Downtime is usually minimal. Small bumps can appear right after treatment and typically settle within hours; any bruising or swelling generally resolves within 1–2 weeks. Makeup can usually be worn from the next day.

Possible side effects

• Small bumps right after treatment, settling within hours.
• Bruising or swelling, generally resolving within 1–2 weeks.
• It’s best to avoid long baths, saunas, alcohol and intense exercise for about a week, and to limit strong sun for 1–2 weeks — worth planning if you are visiting Bangkok.

Once you’ve completed the first three sessions, a maintenance session roughly every six months can help hold onto the result.

Rejuran vs. Rejuran i for Your Concern

Two versions are used depending on the area and how delicate the skin is — choosing the right one matters for under-eye and peri-oral concerns that often sit alongside acne marks.

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Across a plan, the two types can also be combined — standard Rejuran for the cheeks and overall texture, and Rejuran i where the skin is thinner. Your doctor decides the mix based on your concerns.

Pricing at Bibi Clinic in Bangkok

Pricing is by volume per session; the exact volume needed depends on your scarring and the areas treated, confirmed at consultation.

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At Bibi Clinic, injections are performed manually by doctors, allowing careful, area-by-area placement around scars and pores. If pores are a particular concern, the clinic’s Rejuran skin booster page has more detail.

Frequently Asked Questions

Rejuran or Rejuran i for under-eye scarring?

Rejuran i is lighter and suits delicate under-eye skin; standard Rejuran covers cheeks and overall texture.

How much downtime is there?

Minimal. Small bumps settle within hours; any bruising or swelling typically clears within 1–2 weeks.

Can I have Rejuran with a fish allergy?

No — a fish or fish-roe allergy is a contraindication. Tell your doctor your full history at consultation.

Can Rejuran treat deep, crater-like acne scars?

It tends to help most with texture, shallow marks and pores rather than deep, crater-like scars. For deeper scarring, your doctor may suggest combining Rejuran with another treatment, such as resurfacing or subcision.

How many sessions will I need?

A common starting point is three sessions about a month apart, followed by a maintenance session roughly every six months. Your doctor will confirm the right plan at consultation.

References

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Individual results vary. Please consult a qualified medical professional before undergoing any aesthetic treatment. Bibi Clinic’s physicians will assess your personal suitability during a consultation.