Medically reviewed by

Dr. Pim Thaweewitayarut — Board-certified Dermatologist

MSc Dermatology, King’s College London · Best thesis award in acne treatment

Rejuran is an injectable polynucleotide (PN) skin booster derived from salmon DNA that supports skin regeneration. In Bangkok it is a popular non-surgical way to improve firmness, texture and glow.

This guide covers how it works, sessions, downtime and cost.

Table of Contents

The Short Answer

Rejuran is a skin booster made from polynucleotides (PN) extracted from salmon DNA, which is why it is nicknamed the “salmon injection.” Rather than adding volume like a filler, it works from within to support the skin’s own repair process, helping thicken the epidermis and dermis and improving firmness, hydration and texture. A typical plan is three sessions spaced about a month apart, followed by maintenance every six months. Results usually last somewhere between 6 and 12 months, though it depends on the person, and downtime tends to be minimal.

What Is Rejuran?

Rejuran is a skin booster containing polynucleotides (PN), long-chain fragments that support repair, regeneration and renewal in the skin. Unlike a hyaluronic acid filler, which physically plumps a line, Rejuran works on something broader: the overall quality of your skin. Published reviews note that PN compounds may help support tissue repair and calm inflammation.^[1] Day to day, that can look like smoother texture, skin that holds onto moisture better, and a more even, refreshed-looking surface. It can be used across the whole face, and on the forehead, neck and décolletage too.

It’s also different from collagen-stimulating injectables: a filler is about shape, a stimulator gradually nudges the skin into making new collagen for structure, while Rejuran is about the condition of the skin itself. The product used in treatment is approved by the Thai FDA.

The treatment process

1. Cleansing and skin assessment. The doctor checks your skin condition and agrees the injection sites and amount with you.
2. Topical anaesthetic applied before treatment begins.
3. Injection (about 15–30 minutes) performed manually by the doctor.
4. Aftercare guidance, with a follow-up plan of further sessions and maintenance.

Who Is It Suitable For?

Because it works on skin quality rather than shape, Rejuran suits a range of everyday concerns, including loss of firmness and radiance, rough or uneven texture and enlarged-looking pores, fine lines linked to dryness and ageing, the appearance of acne marks and shallow scarring, and under-eye dark circles linked to poor circulation. Rejuran is not a lifting procedure; for pronounced sagging, a doctor may suggest combining it with other treatments.

Treatment is generally not suitable for those who are pregnant, breastfeeding, or may be pregnant; people taking NSAIDs, immunosuppressants, or antiplatelet or anticoagulant medicines; those with autoimmune conditions such as sarcoidosis; anyone with an allergy to fish or fish roe, or hypersensitivity to polynucleotide sodium; and those with active inflammation or infection. Always tell your doctor about allergies and medications at consultation.

Sessions, Results and How Long It Lasts

Many people notice early improvements, such as firmness, glow, and brighter under-eyes, after a single session. For texture, fine lines and acne marks, the recommended plan is three sessions spaced about one month apart, followed by maintenance every six months. Changes in texture and elasticity tend to become clearer over several weeks, and results generally last 6 to 12 months, varying with the formula used and your starting skin condition.

A visit is short: skin is cleansed, a doctor checks your skin condition and agrees the injection sites and amount, a topical anaesthetic is applied, and the injection itself usually takes about 15 to 30 minutes.

Possible side effects

• Small bumps right after treatment, typically settling within a few hours.
• Bruising or swelling, possible and generally resolving within 1–2 weeks.
• It’s wise to avoid long baths, saunas, alcohol and intense exercise for about a week, and prolonged sun exposure for 1–2 weeks.

Injections at Bibi Clinic are performed manually by doctors, not by an automated device, so placement is tailored to each area. For comfort, the clinic also offers a Pain-Free Rejuran formulation alongside topical anaesthesia. Most people return to normal activity the same day.

Rejuran vs. Rejuran i

Rejuran is not a one-size-fits-all product — a lighter version exists for more delicate areas.

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Pricing at Bibi Clinic in Bangkok

Pricing at Bibi Clinic is straightforward and based on the volume used per session; your exact volume is confirmed at consultation, never estimated in advance.

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When comparing clinics, it’s worth looking past the headline number — manual, doctor-led placement allows the dose to be adapted area by area. For the full, current menu, see the Rejuran skin booster page.

Frequently Asked Questions

How long does Rejuran last?

Results generally last 6 to 12 months, depending on the formula and your skin. Maintenance every six months helps sustain them.

Can I see results after just one session?

Many patients notice more firmness and glow after just one session. For texture, fine lines and acne marks, three sessions are generally recommended.

How much downtime does Rejuran need?

Usually minimal. Small bumps settle within hours; any bruising or swelling typically clears within 1–2 weeks.

Is Rejuran painful?

Some discomfort is possible. The clinic uses topical anaesthesia and a pain-reduced formula to keep treatment comfortable.

What’s the difference between Rejuran and Rejuran i?

Rejuran is designed for overall skin rejuvenation across the entire face, while Rejuran i has a lighter formulation specifically developed for delicate areas such as around the eyes.

References

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Individual results vary. Please consult a qualified medical professional before undergoing any aesthetic treatment. Bibi Clinic’s physicians will assess your personal suitability during a consultation.